Dr Suzanne Humphrey
Lecturer
Strathclyde Institute of Pharmacy and Biomedical Sciences
Personal statement
Suzie Humphrey lab
Research in my lab seeks to understand the molecular basis of horizontal gene transfer and the biology of mobile genetic elements in bacteria of clinical importance. Our work principally focusses on determining the contribution of plasmids and bacteriophages to gene exchange, antimicrobial resistance transmission, and host-pathogen interactions in Enterococcus spp. We are also investigating the role of bacteriophages in enabling niche adaptation by Enterocloster spp. during times of intestinal microbiome imbalance, as well as their potential use as alternative therapeutic agents for treating dysbiosis.
Publications
- Bacteriophages benefit from mobilizing pathogenicity islands encoding immune systems against competitors
- Fillol-Salom Alfred, Rostøl Jakob T, Ojiogu Adaeze D, Chen John, Douce Gill, Humphrey Suzanne, Penadés José R
- Cell Vol 185, pp. 3248-3262.e20 (2022)
- https://doi.org/10.1016/j.cell.2022.07.014
- Staphylococcal phages and pathogenicity islands drive plasmid evolution
- Humphrey Suzanne, San Millán Álvaro, Toll-Riera Macarena, Connolly John, Flor-Duro Alejandra, Chen John, Ubeda Carles, MacLean R Craig, Penadés José R
- Nature Communications Vol 12 (2021)
- https://doi.org/10.1038/s41467-021-26101-5
- Bacterial chromosomal mobility via lateral transduction exceeds that of classical mobile genetic elements
- Humphrey Suzanne, Fillol-Salom Alfred, Quiles-Puchalt Nuria, Ibarra-Chávez Rodrigo, Haag Andreas F, Chen John, Penadés José R
- Nature Communications Vol 12 (2021)
- https://doi.org/10.1038/s41467-021-26004-5
- Lateral transduction is inherent to the life cycle of the archetypical Salmonella phage P22
- Fillol-Salom Alfred, Bacigalupe Rodrigo, Humphrey Suzanne, Chiang Yin Ning, Chen John, Penadés José R
- Nature Communications Vol 12 (2021)
- https://doi.org/10.1038/s41467-021-26520-4
- Genomic characterization of prophage elements in Clostridium clostridioforme : an understudied component of the intestinal microbiome
- Humphrey Suzanne, Marouli Angeliki, Thümmler Katja, Mullin Margaret, Pritchard Leighton, Wall Daniel M
- Microbiology Vol 170 (2024)
- https://doi.org/10.1099/mic.0.001486
- Characterisation of novel bacteriophages in a hyper-adapted strain of Clostridium clostridioforme associated with gut microbiome dysbiosis
- Humphrey Suzanne
- Viruses of Microbes UK Annual Conference (2024)
Professional Activities
- Microbiology Society Annual Conference
- Participant
- 10/4/2024
Projects
- Exploiting bacteriophages to treat Enterococcus faecium infections
- Humphrey, Suzanne (Principal Investigator)
- 01-Jan-2025 - 28-Jan-2026
- Investigating the role of Enterocloster clostridioformis bacteriophages in gut microbiome dysbiosis associated with metabolic disease states.
- Humphrey, Suzanne (Principal Investigator)
- 03-Jan-2024 - 02-Jan-2025
Contact
Dr
Suzanne
Humphrey
Lecturer
Strathclyde Institute of Pharmacy and Biomedical Sciences
Email: suzie.humphrey@strath.ac.uk
Tel: 548 3431